Pharmacological Intervention to Prevent Disuse Osteopenia
نویسندگان
چکیده
Departments of Orthopedics and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 ([email protected]); Department of Orthopedics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 ([email protected]); Department of Orthopedics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 ([email protected]); Department of Orthopedics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 ([email protected]); and NASA-Ames Research Center, Moffett Field, CA 94035 ([email protected])
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INTRODUCTION Loss of bone due to disuse osteopenia remains an unsolved and debilitating problem. While some current therapies rely on weightbearing activities to promote new bone growth, disuse osteopenia often occurs in situations in which weight bearing or mechanical loading of bone is impractical, e.g. in bedridden or mobility limited individuals or in microgravity conditions. Hence, new the...
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UNLABELLED The genetic influence on bone loss in response to mechanical unloading was investigated within diaphyseal and distal femoral regions in three genetically distinct strains of mice. One mouse strain failed to lose bone after removal of function, whereas osteopenia was evident in multiple regions of the remaining two strains but in different areas of the bone. INTRODUCTION It is well ...
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Disuse typically causes an imbalance in bone formation and bone resorption, leading to losses of cortical and trabecular bone. In contrast, bears maintain balanced intracortical remodeling and prevent cortical bone loss during disuse (hibernation). Trabecular bone, however, is more detrimentally affected than cortical bone in other animal models of disuse. Here we investigated the effects of hi...
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It is generally believed that mechanical signals must be large in order to be anabolic to bone tissue. Recent evidence indicates, however, that extremely low-magnitude (<10 microstrain) mechanical signals readily stimulate bone formation if induced at a high frequency. We examined the ability of extremely low-magnitude, high-frequency mechanical signals to restore anabolic bone cell activity in...
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